The AFCON champions go into Tuesday’s showdown knowing a win guarantees a spot in the round of 16, and could see them finish as group winners if the Netherlands fail to beat Qatar.
A point seprates the top three in Group A, with Netherlands (1st) and Ecuador (2nd) on four points and Senegal (3rd) three.
A win is likely to be the only result that will send ‘The Lions of Teranga’ into the knockout stages.
In the unlikely event the already-eliminated hosts beat Louis van Gaal’s Oranje, a draw keeps Senegal in contention.
“We have to win if we want to continue with this adventure”, said Cisse, “not going to the round of 16 would be a hard pill to swallow”, the 46-year-old added.